Inside a analyze in breast cancer cells, The mix of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented both HER2 and HER3 phosphorylation induced by INK128 and generated synergistic induction of cell Demise in numerous HER2-positive cell strains proof against trastuzumab and lapatinib. In vivoMeanwhile, to make sur